Genes and Training for Athletic Performance Will G Hopkins Department of Physiology and School of Physical Education,
University of Otago, Dunedin 9001, New Zealand. Email. Sportscience 5(1), sportsci.org/jour/0101/wghgene.htm,
2001 (1899 words)
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A few months ago someone on the Sportscience list initiated a discussion about the possibility that "sport performance and sport expertise is entirely the result of hours spent in focused, effortful training rather than innate, inheritable traits". Adaptation to training is so important, he pointed out, that maybe it swamps any contribution from genes. He also suggested that there was little apparent difference between athletes and non-athletes in basic visual and motor skills, so expert performance might be nothing more than a specific skill or physiological adaptation acquired through specific training. He cited a review (Ericsson et al., 1993) to support these notions. He conceded that height and presumably other features of body build contribute to success in certain sports. He also made the reasonable assertion that training for some sports has to begin at an early age for the individual to have any hope of reaching the top. In the follow-up discussion, several people identified non-inherited factors that affect performance, such as social support. They also identified motivation to train, but it was not clear whether they thought this trait was inherited or acquired. A claim that the abilities of top athletes are innate and acquired was backed up by rhetoric but no evidence; the same writer made the unusual claim that innate abilities are modifiable. Someone injected more objectivity by pointing out that the average person's aerobic power cannot be trained to that of an elite endurance athlete, and that there are obvious differences in the physical abilities of children who have had little or no training. In all this discussion, there was little reference to published work. In particular, no-one referred to the work of the Bouchards (Claude and Thomas J). In my understanding of it, the work of the Bouchards is definitive: genes account typically for half of the variation in performance between individuals. In other words, when you compare the physical performance of individuals, heredity is as important as all other influences combined. The Bouchards have also shown that heredity determines at least half the variation in the response to training, and that therefore inherited differences in performance do not arise simply from an inherited drive to train. To put it another way, if you take a random sample of individuals and train them all the same way, you will not end up with everyone on the same level of performance. Clearly, athletes are individuals who inherit the ability to respond well to training. Claude Bouchard and coworkers based their early work on analysis of performance within and between families, including twins in some studies. The group is now looking at the association between specific DNA sequences and performance. So far they have found little or no association, presumably because performance is determined by many genes and/or they haven't struck gold yet. For a good brief review of the recent and earlier work of Claude Bouchard's group, see the introduction to their paper in the October issue of Medicine and Science in Sports and Exercise (Wolfarth et al., 2000). The comprehensive familial study by another group (Maes et al., 1996) is also an outstanding contribution to this field. The statistics are daunting, but the conclusions about the importance of heredity are clear. Thomas J Bouchard's main claim to fame is studies of twins separated at birth. The closest he and his colleagues got to physical performance is a training study involving a visual skill (Fox et al., 1996). More than half the variation in initial ability was inherited, and the contribution of heredity actually increased with training. In a follow-up message I sent to the Sportscience list, I made the remark that twin studies are probably the best for resolving the nature-nurture debate. Someone commented astutely that the shared prenatal environment, rather than shared genes, could account for the similarities in twins. In other words, the variance explained by genes is really variance explained by experience in utero. This criticism does not apply to the study of Fox et al., who based their analysis on differences between identical and non-identical twins separated at birth. In spite of all the evidence for the role of heredity in physical performance and many other aspects of human behavior, there is still a clique of academics who hold out for the primacy of training and other environmental effects. See for example Howe et al. (1998), who did not discuss or even cite Fox et al. (1996) or Maes et al. (1996). Did they deliberately review the literature in a one-sided adversarial manner, did they not understand the genetics, or did they simply fail to do a literature search? The discovery of a specific performance gene should convince even these academics that heredity contributes to human performance. A promising candidate is the gene for angiotensin converting enzyme (the ACE gene), but at this stage it is hard to reconcile the conflicting findings of the relative effects of the two forms of this gene on training and performance (Montgomery et al., 1997; Gayagay et al., 1998; Montgomery et al., 1998; Taylor et al., 1999; Fatini et al., 2000; Rankinen et al., 2000). The genetics research has focussed either on the general population or on differences between athletes and non-athletes, but what can we say about the relative contributions of genes and training to performance of elite athletes? There is bound to be less genetic diversity amongst these athletes, because the process by which athletes reach the top in a given sport must result in selection for certain genes. But the same selection pressures probably result in less diversity in the training programs of such athletes, so according to this logic the contribution of heredity may still be about the same as in the general population. Heredity may be even more important in athletes, because an athlete's ability to sustain high training loads without overtraining is probably inherited. What are the practical implications of the fact that athletes are born and made? Here are a few:
The reviewer of this article made the following comments. I don’t think there is any doubt that genes make a contribution to performance. You have cited evidence for 50%. I am not sure I believe 50%, but 50% is in the right ballpark. In the next decade, the exact contribution will be known using technology that is coming on track through the Human Genome Project. The term "unethical" in relation to genotyping of athletes needs some sort of explanation. Unethical refers to the abuse of drugs or other forms of cheating. I wouldn’t equate cheating with the use of DNA markers to identify an elite athlete. In my opinion, using DNA markers is no different to saying to a very short person that he/she will not be chosen for the national basketball team because of their height. Everyone gets very uptight when DNA or genes are mentioned in connection with athletes, yet there is no objection to using DNA to identify diseases or criminals. A coach's career will not last long if the coach selects athletes only on the basis of DNA. However, a coaching career might flourish if the coach gets ahead of rivals by adding DNA information to other selection criteria and good training. I cannot see that such behavior is unethical. References For the recent messages posted to the Sportscience list on this topic, click here. See also the links to other articles on genes at this site Ericsson KA, Krampe RT, Tesch-Romer C (1993). The role of deliberate practice in the acquisition of expert performance. Psychological Review 100, 363-406 Fatini C, Guazzelli R, Manetti P, Battaglini B, Gensini F, et al. (2000). RAS genes influence exercise-induced left ventricular hypertrophy: an elite athletes study. Medicine and Science in Sports and Exercise 32, 1868-1872 Fox PW, Hershberger SL, Bouchard TJ (1996). Genetic and environmental contributions to the acquisition of a motor skill. Nature 384, 356-358 Gayagay G, Yu B, Hambly B, Boston T, Hahn A, et al. (1998). Elite endurance athletes and the ACE I allele - the role of genes in athletic performance. Human Genetics 103, 48-50 Howe MJA, Davidson JW, Sloboda JA (1998). Innate talents: reality or myth? Behavioral and Brain Sciences 21, 399-442 (includes peer commentary) Maes HHM, Beunen GP, Vlietinck RF, Neale MC, Thomis M, et al. (1996). Inheritance of physical fitness in 10-yr-old twins and their parents. Medicine and Science in Sports and Exercise 28, 1479-1491 Montgomery HE, Clarkson P, Dollery CM, Prasad K, Losi MA, et al. (1997). Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training. Circulation 96, 741-747 Montgomery HE, Marshall R, Hemingway H, Myerson S, Clarkson P, et al. (1998). Human gene for physical performance. Nature 393, 221-222 Rankinen T, Perusse L, Gagnon J, Chagnon YC, Leon AS, et al. (2000). Angiotensin-converting enzyme ID polymorphism and fitness phenotype in the HERITAGE Family Study. Journal of Applied Physiology 88, 1029-1035 Taylor RR, Mamotte CDS, Fallon K, van Bockxmeer FM (1999). Elite athletes and the gene for angiotensin-converting enzyme. Journal of Applied Physiology 87, 1035-1037 Wolfarth B, Rivera MA, Oppert JM, Boulay MR, Dionne FT, et al. (2000). A polymorphism in the alpha(2a)-adrenoceptor gene and endurance athlete status. Medicine and Science in Sports and Exercise 32, 1709-1712 ©2001 |